Evidence map›Paper›PMID 41648756›Full record

Trial reportFrontiers in nutrition2025

Eight weeks of treatment with probiotic

Ida Marie Bruun Grønbæk, Sofie Ingdam Halkjær, Esben Holm Hansen, Sarah Mollerup, Sarah Juel Paulsen, Christina Valbirk Konrad, Sara Engel, Magdalena Bulinska-Balas, Anja Wellejus, Anne Birgitte Haaber and 3 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04808271 (The Effects of Bifidobacterium Breve Bif195 for Diarrhea-predominant Irritable Bowel Syndrome), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04808271 nacompletednot on this map

The Effects of Bifidobacterium Breve Bif195 for Diarrhea-predominant Irritable Bowel Syndrome: a Double-blind, Randomized, Placebo-controlled Study

TypeinterventionalSponsorHvidovre University HospitalRan2021 to 2023Enrolled61ConditionsIrritable Bowel SyndromeArmsBifidobacterium breve Bif195, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ida Marie Bruun GrønbækGastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Sofie Ingdam HalkjærGastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Esben Holm HansenGastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Sarah MollerupDepartment of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Sarah Juel PaulsenDepartment of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Christina Valbirk KonradDepartment of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Sara EngelChr. Hansen A/S, Part of Novonesis, Human Health Biosolutions, Hørsholm, Denmark.
Magdalena Bulinska-BalasChr. Hansen A/S, Part of Novonesis, Human Health Biosolutions, Hørsholm, Denmark.
Anja WellejusChr. Hansen A/S, Part of Novonesis, Human Health Biosolutions, Hørsholm, Denmark.
Anne Birgitte HaaberMavespecialisten, Charlottenlund, Denmark.
Alice Højer ChristensenAleris Hospitals Copenhagen, Søborg, Denmark.
Anne Line EngsbroDepartment of Clinical Microbiology, Zealand University Hospital, Slagelse, Denmark.
Andreas Munk PetersenGastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with irritable bowel syndrome experience abdominal pain and stool habit disturbances, and often also extraintestinal symptoms, such as fatigue. The disorder is linked to gut dysbiosis, and manipulation of the microbiota is considered a possible treatment strategy. This randomised, double-blinded, placebo-controlled study aimed to investigate the effects of the probiotic strain Clinical trial registration: clinicaltrials.gov, identifier NCT04808271.

Indexed as

Bifidobacterium brevefatiguegut microbiotairritable bowel syndromeprobiotic treatmentshotgun metagenomicstransepithelial electrical resistance

Identifiers

PMID41648756
PMCPMC12869991

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.