ArticleAdvanced materials technologies2025
Evaporation-Enhanced Redox Cycling for Rapid Detection of Attomolar SARS-CoV-2 Virions Using Nanolithography-Free Electrochemical Devices.
Article in Advanced materials technologies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Selective Wettability-Driven Evaporation-Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles.Small methods · 2026Article
- Advanced Technologies in Extracellular Vesicle Biosensing: Platforms, Standardization, and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Multi-Electrode Extended Gate Field Effect Transistors Based on Laser-Induced Graphene for the Detection of Vitamin C and SARS-CoV-2.ACS applied materials & interfaces · 2024Article
- Systematic Study of Various Functionalization Steps for Ultrasensitive Detection of SARS-CoV-2 with Direct Laser-Functionalized Au-LIG Electrochemical Sensors.ACS applied materials & interfaces · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In fighting against infectious diseases such as COVID-19, simple-to-use, sensitive, scalable, and rapid diagnostics are crucial for early disease diagnosis. In this regard, electrochemical biosensors are particularly attractive in developing point-of-need diagnostics. Importantly, by being compatible with nano- and microfabrication methods, they are amenable to miniaturization, which reduces background noise and the required sample volume. However, miniaturization also reduces the signal level, making it challenging to detect low virus counts. In this work, microfabricated electrochemical sensors with a dual signal amplification scheme based on evaporation-enhanced redox cycling (E2RC) in a generator-collector configuration are developed. A scalable, nanolithography-free fabrication method is proposed to achieve a controllable sub-micrometer gap between three dimensional (3D) interdigitated microelectrodes by combining photolithography with template-driven electrodeposition. Using the optimized electrodes, the sensors achieve rapid detection with a limit of quantification of ≈1.2 × 10
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Registered trials
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