Evidence map›Paper›PMID 41648662›Full record

ArticleiMetaOmics2025

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes.

Xiyue Chen, Zhihao Jia, Xiashiyao Zhang, Feng Yue, James F Markworth, Christina R Ferreira, Jun Wan, Shihuan Kuang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMetaOmics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiyue ChenDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0009-0007-0598-6189
Zhihao JiaDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-5525-2721
Xiashiyao ZhangDepartment of BioHealth Informatics, Luddy School of Informatics and Computing, Indiana University at Indianapolis, Indianapolis, Indiana, USA.
Feng YueDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
James F MarkworthDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
Christina R FerreiraMetabolite Profiling Facility, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-3988-6454
Jun WanDepartment of BioHealth Informatics, Luddy School of Informatics and Computing, Indiana University at Indianapolis, Indianapolis, Indiana, USA.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-9180-3180

Funding

Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelR01AR079235 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2022 to 2025
$1.3M
NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R01 AR079235NIDDK NIH HHS R01 DK132819
6 · The paper itself

Abstract

The adipose tissue (AT) is a main regulator of systemic energy homeostasis, and AT dysfunction leads to insulin resistance and other metabolic complications. Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetrical dimethylation of arginine residues to modulate protein stability and function. Besides its well-studied oncogenic functions, PRMT5 has recently been shown to play a physiological role in AT through poorly understood mechanisms. Here, we explore the function of PRMT5 in AT through unbiased RNA sequencing and lipidomic analyses of AT in wild-type and adipocyte-specific

Indexed as

adipocytescholesterol synthesismembrane transportprotein methylation

Identifiers

PMID41648662
PMCPMC12806136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.