Evidence map›Paper›PMID 41648627›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural basis for dimerization, catalytic regulation, and substrate selectivity in S9D proteases.

Jacqueline J Ehrlich, Pratyush Routray, Louis Enns, Klaas J van Wijk, Toshimitsu Kawate

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jacqueline J EhrlichDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-8761-7198
Pratyush RoutraySchool of Integrative Plant Science, Plant Biology Section, Cornell University, Ithaca, NY 14853, USA.
Louis EnnsDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0000-8453-7638
Klaas J van WijkSchool of Integrative Plant Science, Plant Biology Section, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-9536-0487
Toshimitsu KawateDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-5005-2031

Funding

Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
Structure and Function of Pannexins: Activation MechanismR01GM114379 · NIGMS · CORNELL UNIVERSITY · PI KAWATE, TOSHIMITSU · 2015 to 2025
$3.1M
Cryo Transmission Electron Microscope for Cryo-EM Sample OptimizationS10OD030470 · OD · CORNELL UNIVERSITY · PI KELLOGG, ELIZABETH · 2021 to 2021
$1.1M
NIGMS NIH HHS R01 GM114379NIGMS NIH HHS R24 GM154185NIH HHS S10 OD030470
6 · The paper itself

Abstract

S9 proteases are widely distributed across the tree-of-life and play essential roles in protein processing. However, the structural and mechanistic basis for protease activity in the S9D subfamily has remained unknown. Here, we report the first high-resolution cryo-EM structures of an S9D protease, chloroplast glutamyl endopeptidase (CGEP) from

Indexed as

chloroplast proteostasiscryo-electron microscopyglutamyl endopeptidaseS9 protease family

Identifiers

PMID41648627
PMCPMC12871690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.