ArticlebioRxiv : the preprint server for biology2026
The nuclear receptor ROR-alpha is a critical myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: We recently found that the nuclear receptor retinoic acid-related orphan nuclear receptor alpha (RORα) protects against angiotensin II-induced cardiac hypertrophy and promotes cardiomyocyte mitophagy. The underlying molecular basis for these salutary effects remains unclear. Methods: We used RNA microarrays to profile the cardiac transcriptomes of "staggerer" (RORα Results: The absence of functional RORα results in broad transcriptional changes in the heart providing a likely molecular basis for the RORα Conclusions: Collectively these findings position RORα as a previously unrecognized central regulator of the cardiac myogenic transcriptome and the first recognized transcriptional regulator of
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