Evidence map›Paper›PMID 41648620›Full record

ArticlebioRxiv : the preprint server for biology2026

A Mammalian Surface Display Platform to Optimize the Antigenicity of Viral Proteins for Vaccine Design.

Jayani Christopher, Caitlin Harris, Daniel J Marston, Brianna Rhodes, McKenzie Frazier, Mihai L Azoitei

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jayani ChristopherDuke Human Vaccine Institute, Duke University, Durham, NC, USA.ORCID 0009-0002-0465-3503
Caitlin HarrisDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Daniel J MarstonDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Brianna RhodesDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
McKenzie FrazierDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Mihai L AzoiteiDuke Human Vaccine Institute, Duke University, Durham, NC, USA.ORCID 0000-0002-4080-1350

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine development often involves modifying native viral proteins to enhance their stability and antigenicity, as seen in approved Covid-19 vaccines and multiple HIV vaccine candidates currently under investigation. High throughput screening on the surface of mammalian cells enables the rapid evaluation of oligomeric, glycosylated viral proteins and the identification of mutations that improve their properties for vaccine design. Here, we developed an experimental platform that uses the

Identifiers

PMID41648620
PMCPMC12871315

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.