ArticlebioRxiv : the preprint server for biology2026
Amplified genome editing by
Wayne Ngo, Daniel Rosas-Rivera, Kevin M Wasko, Longhui Qiu, Min Hyung Kang, Shaan Gogna, Jingkun Zeng, Mason T Hooks, Jamie L Y Wu, Zhongmei Li and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Daniel Rosas-RiveraInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Kevin M WaskoInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Longhui QiuDepartment of Medicine, University of California, San Francisco; San Francisco, CA, USA.
Min Hyung KangInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Shaan GognaInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Jingkun ZengInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Mason T HooksInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Jamie L Y WuInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.
Zhongmei LiGladstone-UCSF Institute of Genomic Immunology; San Francisco, CA, USA.
Jennifer A DoudnaInnovative Genomics Institute; University of California, Berkeley; Berkeley CA, USA.ORCID 0000-0001-9161-999X Funding
Project 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDREJ SALI · 2022 to 2026
$35.7MRESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDREJ SALI · 2018 to 2026
$21.4MResource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIREN MURTHY · 2023 to 2026
$19.7MExpanding CRISPR-Cas editing technology through exploration of novel Cas proteins and DNA repair systemsU01AI142817 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BANFIELD, JILLIAN, DOUDNA, JENNIFER A · 2018 to 2022
$2.0MCas9 RNP delivery to immune cells in vivo via molecular targetingUH3AI150552 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI DOUDNA, JENNIFER A, WILSON, ROSS C · 2022 to 2022
$1.3MBD FACSAria II Flow CytometerS10RR028962 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI CAVROIS, MARIELLE · 2011 to 2011
$544kTargeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery VehiclesR21HL173710 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI DOUDNA, JENNIFER A · 2024 to 2025
$520kNCRR NIH HHS S10 RR028962NHLBI NIH HHS R21 HL173710NIAID NIH HHS U01 AI142817NIAID NIH HHS U19 AI135990NIAID NIH HHS U54 AI170792NIAID NIH HHS UH3 AI150552NINDS NIH HHS U19 NS132303
6 · The paper itselfAbstract
Genome editing enzymes have vast therapeutic potential. However, achieving sufficient delivery
Identifiers
PMID41648602
PMCPMC12871335
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