ArticlebioRxiv : the preprint server for biology2026
RNA Structure Coordinates Translation Across the Meiotic Program.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
mRNA structure is a key determinant of translation efficiency for individual transcripts, yet its role in coordinating complex physiological processes remains elusive. We profiled mRNA structures during yeast meiosis, deriving a high-resolution structurome covering ~70% of annotated mRNAs, with multi-time-point measurements for 2,084 mRNAs. Transcripts upregulated during meiosis generally have flexible structures that enhance translation. In contrast, complex structures impede translation during meiosis by reducing ribosome flux in coding regions and promoting alternative initiation, including in the highly abundant transcript
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