Evidence map›Paper›PMID 41648598›Full record

ArticlebioRxiv : the preprint server for biology2026

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity.

Xiaolei Cai, Min Chen, Guoshuai Cao, Nicholas Asby, Derek Elli, Haley Gula, Vlad Nicolaescu, Duy-Thuc Nguyen, Xiaodan Huang, Tanushree Dangi and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Xiaolei CaiPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Min ChenPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Guoshuai CaoPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Nicholas AsbyPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Derek ElliDepartment of Microbiology, Howard Taylor Ricketts Laboratory, University of Chicago, Chicago, IL 60637, USA.
Haley GulaDepartment of Microbiology, Howard Taylor Ricketts Laboratory, University of Chicago, Chicago, IL 60637, USA.
Vlad NicolaescuDepartment of Microbiology, Howard Taylor Ricketts Laboratory, University of Chicago, Chicago, IL 60637, USA.
Duy-Thuc NguyenPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Xiaodan HuangPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Tanushree DangiBeth Israel Deaconess Medical Center, Havard Medical School, Boston, MA 02215.
Ani SolankiAnimal Resource Center, University of Chicago, Chicago, IL 60637, USA.
Sara WoessnerPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Wenbo ZhangPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Erting TangPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Lisa VolpattiPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Rachel WallacePritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Tony PanPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Mindy NguyenAnimal Resource Center, University of Chicago, Chicago, IL 60637, USA.
Qing ChenPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Zhi GengPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Rohin SagarPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Aaron Esser-KhanPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Pablo Penaloza-MacMasterBeth Israel Deaconess Medical Center, Havard Medical School, Boston, MA 02215.
Dominique MissiakasDepartment of Microbiology, Howard Taylor Ricketts Laboratory, University of Chicago, Chicago, IL 60637, USA.
Jun HuangPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Funding

Molecular mechanism of natural killer cell recognitionDP2AI144245 · NIAID · UNIVERSITY OF CHICAGO · PI HUANG, JUN · 2018 to 2022
$2.9M
NIAID NIH HHS DP2 AI144245
6 · The paper itself

Abstract

mRNA vaccines have transformed prophylactic immunization against infectious diseases as well as therapeutic interventions for cancer. However, their effectiveness against emerging viral variants and a range of malignancies continues to be hindered by suboptimal induction of T cell-mediated immunity. To overcome this limitation, here we developed a polymer-lipid hybrid nanoparticle (PLNP) platform engineered to improve mRNA delivery to antigen-presenting cells (APCs) and to potentiate T cell responses. Relative to conventional mRNA lipid nanoparticle (LNP) vaccines, mRNA PLNP vaccines demonstrated markedly improved lymph node targeting, APC activation, Th1-biased pro-inflammatory cytokine response, and antigen-specific T cell expansion while retaining robust humoral immunity. Remarkably, mRNA-PLNP vaccines generated approximately 50% more antigen-specific CD8

Identifiers

PMID41648598
PMCPMC12871792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.