Evidence map›Paper›PMID 41648589›Full record

ArticlebioRxiv : the preprint server for biology2026

Mechanobiological Specialization of Choroid Plexus Macrophages Defined by Titin Expression.

Sagar Bhatta, Alayna Grzybowski, Gion Ortiz, Marcello DiStasio

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sagar BhattaDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
Alayna GrzybowskiDepartment of Pathology Yale School of Medicine, New Haven, CT.
Gion OrtizProgram in Forensic Science, University of New Haven, New Haven, CT.
Marcello DiStasioDepartment of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-6588-0713

Funding

Mechanisms of proinflammatory glial activation in retinal degenerationK08EY033013 · NEI · YALE UNIVERSITY · PI Marcello Michael DiStasio · 2024 to 2026
$842k
NEI NIH HHS K08 EY033013
6 · The paper itself

Abstract

Functioning both as the site of cerebrospinal fluid production and as an interface between the peripheral circulation and the central nervous system, the choroid plexus (ChP) modulates the gating of immune cells and signals from the periphery as they pass from the blood into cerebrospinal fluid. We generated a single-nucleus and spatial transcriptomic atlas of the adult human ChP, in donors with and without Alzheimer's disease (AD), revealing transcriptionally and spatially distinct macrophage states. We identified a previously unrecognized population of titin-expressing (TTN

Indexed as

Alzheimer’s diseaseBorder-associated macrophagesChoroid plexusCytoskeletal remodelingMechanotransductionSingle-nucleus RNA sequencingSpatial transcriptomicsTitin (TTN)

Identifiers

PMID41648589
PMCPMC12871741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.