ArticlebioRxiv : the preprint server for biology2026
Dynamic engagement of the motor cortex in controlling movement.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Neural circuits do not contribute equally or continuously to behavior. In mice, the motor cortex can be essential or dispensable for movement in different contexts, but how it is dynamically recruited as behavioral demands evolve remains unclear. Here, we demonstrate that motor cortical involvement in movement exhibits rapid, discrete state transitions even during movements that otherwise appear continuous. While robust and reproducible across animals, the timing and presence of these state transitions are highly sensitive to task structure. We find that motor cortical engagement is sustained under conditions of sensorimotor uncertainty and dissipates rapidly when sensorimotor contingencies are resolved and actions and outcomes thus become predictable. These findings reveal a previously unrecognized layer of fast-timescale flexibility in the neural control of movement and offer a conceptual framework for understanding how cortical circuits dynamically govern behavior as demands evolve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.