Evidence map›Paper›PMID 41648577›Full record

ArticlebioRxiv : the preprint server for biology2026

Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure.

Katrina Blandino, Yingchu He, Lifen Htet, Shadeh Okoudjou, Jonathan Lee, Maia Chinatti, Katie Ahn, Mike Lewis, Sarah Gray, Klaus Miczek and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Katrina BlandinoNeuroscience Program, Tufts University School of Medicine, Boston, MA 02111, USA.
Yingchu HeNeuroscience Department, Tufts University School of Medicine, Boston, MA 02111, USA.
Lifen HtetNeuroscience Department, Tufts University School of Medicine, Boston, MA 02111, USA.
Shadeh OkoudjouBuilding Diversity in Biomedical Sciences (BDBS) Program, Tufts University School of Medicine, Boston, MA 02111, USA.
Jonathan LeeTufts University, Medford, MA, 02155, USA.
Maia ChinattiTufts University, Medford, MA, 02155, USA.
Katie AhnTufts University, Medford, MA, 02155, USA.
Mike LewisSAGE Therapeutics, Inc., Cambridge, MA 02142, USA.
Sarah GraySAGE Therapeutics, Inc., Cambridge, MA 02142, USA.
Klaus MiczekTufts University, Medford, MA, 02155, USA.
Jamie MaguireNeuroscience Department, Tufts University School of Medicine, Boston, MA 02111, USA.

Funding

Stress-induced impairments in endogenous neurosteroid signaling in the BLA negatively impacts network and behavioral statesR01MH128235 · NIMH · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2021 to 2025
$2.5M
Building Diversity in Biomedical SciencesR25HL007785 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2008 to 2024
$2.0M
Interneurons tune the neural circuits mediating the anxiolytic effects of alcoholR01AA026256 · NIAAA · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2018 to 2022
$1.9M
NHLBI NIH HHS R25 HL007785NIAAA NIH HHS R01 AA026256NIMH NIH HHS R01 MH128235
6 · The paper itself

Abstract

Alcohol use disorder is a major public health concern worldwide and there is a high comorbidity with psychiatric disorders. The basolateral amygdala (BLA) has been implicated in both mood and alcohol use disorders; however, the mechanisms contributing to the shared pathophysiology remain unknown. Extensive evidence indicates that ethanol modulates GABAergic signaling in the BLA, including actions on neurosteroid-sensitive, extrasynaptic δ subunit-containing GABA

Identifiers

PMID41648577
PMCPMC12871643

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.