Evidence map›Paper›PMID 41648571›Full record

ArticlebioRxiv : the preprint server for biology2026

Discovery of the Phosphonate Flavophos Produced by

Max A Simon, Josseline S Ramos-Figueroa, Vanessa Reyes Lopez, Chayanid Ongpipattanakul, Lingyang Zhu, Constantin Giurgiu, Zoe A Hoffpauir, Audrey L Lamb, Satish K Nair, Wilfred A van der Donk

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Max A SimonDepartment of Bioengineering and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0002-4183-8040
Josseline S Ramos-FigueroaDepartment of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0002-7377-8484
Vanessa Reyes LopezDepartment of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0009-0003-2127-3956
Chayanid OngpipattanakulDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0003-1421-2410
Lingyang ZhuSchool of Chemical Sciences NMR Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0002-6657-271X
Constantin GiurgiuDepartment of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0003-0145-0110
Zoe A HoffpauirDepartment of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249.ORCID 0000-0002-0316-0750
Audrey L LambDepartment of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249.ORCID 0000-0002-2352-2130
Satish K NairDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0003-1790-1334
Wilfred A van der DonkDepartment of Bioengineering and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0002-5467-7071

Funding

Structure, Function, and Engineering of RiPP Biosynthetic EnzymesR35GM151874 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Satish K Nair · 2024 to 2026
$1.8M
NIGMS NIH HHS R35 GM151874
6 · The paper itself

Abstract

Phosphonate natural products have proven value to society as antibiotics and herbicides, and inhibit a range of enzyme targets usually by mimicking the enzyme substrates. In this study, we investigate a family of phosphonate biosynthetic gene clusters (BGCs) found in

Identifiers

PMID41648571
PMCPMC12871164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.