Evidence map›Paper›PMID 41648563›Full record

ArticlebioRxiv : the preprint server for biology2026

Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions across development.

Amanda E Friedman, Michele Perni, Josephine Millard, Damjan Karanfilovski, Michael Granato, Philip D Campbell

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Amanda E FriedmanDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Michele PerniDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Josephine MillardDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Damjan KaranfilovskiDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Michael GranatoDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Philip D CampbellDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.

Funding

Cellular and molecular analysis of startle modulationR01NS118921 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2021 to 2025
$2.6M
Mitochondrial mechanisms underlying neural stem and progenitor cell proliferation deficits in 22q11.2 deletion syndromeK08NS135125 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Philip Campbell · 2024 to 2026
$694k
NINDS NIH HHS K08 NS135125NINDS NIH HHS R01 NS118921
6 · The paper itself

Abstract

Mutations in the human neurexin 1 (NRXN1) gene are associated with neurodevelopmental disorders including autism and schizophrenia. Vertebrate NRXN1 produces three major NRXN1 isoforms, named

Identifiers

PMID41648563
PMCPMC12871855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.