Evidence map›Paper›PMID 41648543›Full record

ArticlebioRxiv : the preprint server for biology2026

Mitochondrial cardiolipin sequestration of caspofungin underlies

Anna K Loksztejn, Rajendra Upadhya, Eduardo A Caro, David M Gooden, Adi Yona, Porter K Ellis, Micha Fridman, Maria A Schumacher, Richard G Brennan, Maureen J Donlin and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna K LoksztejnDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0009-0002-1134-7731
Rajendra UpadhyaDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7613-2518
Eduardo A CaroDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-4312-2844
David M GoodenSmall Molecule Synthesis Facility, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-1447-7235
Adi YonaSchool of Chemistry, Faculty of Exact Sciences Tel Aviv University, Israel.ORCID 0000-0003-0627-3934
Porter K EllisDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-1567-1643
Micha FridmanSchool of Chemistry, Faculty of Exact Sciences Tel Aviv University, Israel.ORCID 0000-0002-2009-7490
Maria A SchumacherDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-5264-1120
Richard G BrennanDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7647-485X
Maureen J DonlinDepartment of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-7312-079X
Jennifer K LodgeDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-2526-1210

Funding

Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular levelR35GM130290 · NIGMS · DUKE UNIVERSITY · PI Maria Schumacher · 2019 to 2026
$4.9M
ROLE OF CELL WALL INTEGRITY IN ECHINOCANDIN RESISTANCE IN C. NEOFORMANSR01AI123407 · NIAID · WASHINGTON UNIVERSITY · PI DONLIN, MAUREEN J, LODGE, JENNIFER K. · 2017 to 2021
$1.9M
Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7S10OD028703 · OD · DUKE UNIVERSITY · PI SODERLING, SCOTT H · 2020 to 2020
$695k
NIAID NIH HHS R01 AI123407NIGMS NIH HHS R35 GM130290NIH HHS S10 OD028703
6 · The paper itself

Abstract

Cryptococcus exhibits inherent resistance to the echinocandin, caspofungin, which inhibits the synthesis of (1,3)-β-D-glucan, a key component of the polysaccharide cell wall. The essential

Identifiers

PMID41648543
PMCPMC12871599

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.