Evidence map›Paper›PMID 41648514›Full record

ArticlebioRxiv : the preprint server for biology2026

Starvation-independent alarmone production inhibits translation through GTP depletion.

Kevin A England, Aude Trinquier, Leah K McKinney, Jue D Wang, Heather A Feaga

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kevin A EnglandDepartment of Microbiology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-8574-9720
Aude TrinquierDepartment of Bacteriology, University of Wisconsin, Madison, WI, 53706, USA.ORCID 0000-0003-1188-2005
Leah K McKinneyDepartment of Bacteriology, University of Wisconsin, Madison, WI, 53706, USA.ORCID 0009-0004-5101-8822
Jue D WangDepartment of Bacteriology, University of Wisconsin, Madison, WI, 53706, USA.ORCID 0000-0003-1503-170X
Heather A FeagaDepartment of Microbiology, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0007-3190-5135

Funding

The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteriaR35GM127088 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Jue D. Wang · 2018 to 2026
$3.9M
Ribosome Quality Control Mechanisms in Gram-Positive BacteriaR35GM147049 · NIGMS · CORNELL UNIVERSITY · PI Heather Feaga · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM127088NIGMS NIH HHS R35 GM147049
6 · The paper itself

Abstract

Bacteria produce the alarmone nucleotides (p)ppGpp during stress to affect replication, transcription, translation, and metabolism. Recently, pGpp was identified as a third alarmone that is produced from the hydrolysis of (p)ppGpp. Although pGpp is a major component of bacterial stress responses, its precise role in mediating these responses is poorly understood. ppGpp and pppGpp bind translation GTPases and therefore directly affect translation to conserve resources during periods of stress. Here, we show that while pGpp is a weaker inhibitor of protein synthesis than ppGpp and pppGpp

Identifiers

PMID41648514
PMCPMC12871298

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.