Evidence map›Paper›PMID 41648512›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY.

L Peyton Russelburg, Merve Demir, Karina Cedeno, Sheila S David, Martin P Horvath

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

L Peyton RusselburgSchool of Biological Sciences, University of Utah, 257 South 1400 East, Salt Lake City, Utah, 84115, USA.ORCID 0000-0001-9627-5452
Merve DemirDepartment of Chemistry, Chemistry and Chemical Biology Graduate Program, University of California Davis, One Shields Avenue, Davis, California, 95616, USA.ORCID 0000-0002-5721-8268
Karina CedenoSchool of Biological Sciences, University of Utah, 257 South 1400 East, Salt Lake City, Utah, 84115, USA.ORCID 0000-0003-4649-1661
Sheila S DavidDepartment of Chemistry, Chemistry and Chemical Biology Graduate Program, University of California Davis, One Shields Avenue, Davis, California, 95616, USA.ORCID 0000-0001-5873-7935
Martin P HorvathSchool of Biological Sciences, University of Utah, 257 South 1400 East, Salt Lake City, Utah, 84115, USA.ORCID 0000-0003-3057-9722

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Eliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5M
Pilatus 6mS10OD021832 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, PAUL DAVID · 2016 to 2016
$980k
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM124149NIH HHS S10 OD021832
6 · The paper itself

Abstract

MutY excises adenine (A) from 8-oxo-guanine:adenine (OG:A) lesions in DNA to initiate base excision repair (BER) and thereby prevent mutations. A catalytic Glu, found at position 43 in the enzyme from

Identifiers

PMID41648512
PMCPMC12871665

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.