Evidence map›Paper›PMID 41648503›Full record

ArticlebioRxiv : the preprint server for biology2026

Spatial control of genome editing activity enables localized immunotherapy.

Xiaoyue Yang, Laura Tong, Yidan Pan, Jin Huang, Zhongchao Yi, Daheng He, Jingpeng Liu, Chi Wang, Ying Liang, Sheng Tong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyue YangF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40536, USA.
Laura TongDepartment of Bioengineering, Stanford University, Stanford, California 94305, USA.
Yidan PanDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Jin HuangCollege of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.
Zhongchao YiF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40536, USA.
Daheng HeDivision of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA.
Jingpeng LiuDivision of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA.
Chi WangDivision of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA.
Ying LiangNew York Blood Center, New York, New York 10065, USA.
Sheng TongF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40536, USA.ORCID 0000-0001-8632-7933

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Controllable In Vivo Genome Editing for Immune-Checkpoint Blockade in Solid TumorsR01EB026893 · NIBIB · UNIVERSITY OF KENTUCKY · PI TONG, SHENG · 2018 to 2022
$2.0M
NCI NIH HHS P30 CA177558NIBIB NIH HHS R01 EB026893
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41648503
PMCPMC12871275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.