Evidence map›Paper›PMID 41648476›Full record

ArticlebioRxiv : the preprint server for biology2026

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation.

Isaac J Fisher, Kanishka Senarath, Kennedy Outlaw, Kaushik Muralidharan, Elisabeth E Garland-Kuntz, Michelle Van Camp, Tommy Komay, Asuka Inoue, Eva Kostenis, Nevin A Lambert and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Isaac J FisherJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Kanishka SenarathDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Kennedy OutlawJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Kaushik MuralidharanDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Elisabeth E Garland-KuntzJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Michelle Van CampJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Tommy KomayJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Eva KostenisMolecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.ORCID 0000-0001-8284-5514
Nevin A LambertDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0001-7550-0921
Angeline M LyonJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID 0000-0001-7501-0148

Funding

Structural Studies of PLCepsilon a regulator of cardiac contractility and hypertrophy.R01HL141076 · NHLBI · PURDUE UNIVERSITY · PI Angeline Marie Lyon · 2018 to 2026
$2.5M
Conventional and unconventional GPCR-G protein couplingR35GM145284 · NIGMS · AUGUSTA UNIVERSITY · PI Nevin Alan Lambert · 2022 to 2026
$1.8M
Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteinsR01GM152701 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon · 2024 to 2026
$1.1M
Structural Characterization of Gbetagamma-Phospholipase C complexesF32GM145110 · NIGMS · PURDUE UNIVERSITY · PI FISHER, ISAAC · 2022 to 2023
$142k
NHLBI NIH HHS R01 HL141076NIGMS NIH HHS F32 GM145110NIGMS NIH HHS R01 GM152701NIGMS NIH HHS R35 GM145284
6 · The paper itself

Abstract

Phospholipase C β (PLCβ) enzymes are activated by heterotrimeric G protein subunits, increasing hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2) at the plasma membrane. All four human PLCβ isoforms (PLCβ1-4) are activated by Gα

Indexed as

BiochemistryBiological SciencesGαqGβγphospholipasePIP2PLCβ

Identifiers

PMID41648476
PMCPMC12871268

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.