Evidence map›Paper›PMID 41648446›Full record

ArticlebioRxiv : the preprint server for biology2026

Iterative Bump-and-hole engineering creates a bioorthogonal reporter for

Yu Liu, Saskia Pieters, Ganka Bineva-Todd, Mert Sagiroglugil, Sean A Burnap, Freya Hoddle, Anna Cioce, Andre Ohara, Kevin Bruemmer, Carolyn R Bertozzi and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yu LiuDepartment of Chemistry, Imperial College London, W12 0BZ, London, United Kingdom.
Saskia PietersDepartment of Chemistry, Imperial College London, W12 0BZ, London, United Kingdom.
Ganka Bineva-ToddChemical Glycobiology Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.
Mert SagiroglugilDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Sean A BurnapDepartment of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford OX1 3QU, United Kingdom.
Freya HoddleDepartment of Chemistry, Imperial College London, W12 0BZ, London, United Kingdom.
Anna CioceDepartment of Chemistry, Imperial College London, W12 0BZ, London, United Kingdom.
Andre OharaDepartment of Chemical Engineering, Imperial College London, London, UK.
Kevin BruemmerStanford Sarafan ChEM-H, Stanford University, Stanford, California 94305, USA.
Carolyn R BertozziStanford Sarafan ChEM-H, Stanford University, Stanford, California 94305, USA.
Karen PolizziDepartment of Chemical Engineering, Imperial College London, London, UK.
Weston B StruweDepartment of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0003-0594-226X
Carme RoviraDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Benjamin SchumannDepartment of Chemistry, Imperial College London, W12 0BZ, London, United Kingdom.ORCID 0000-0001-5504-0147

Funding

ZINC DEFICIENCY &PROTEIN EXPRESSION IN RAT OLFACTORY BULBSP41RR005351 · NCRR · UNIVERSITY OF GEORGIA (UGA) · PI AZADI, PARASTOO · 1989 to 2011
$18.4M
NCRR NIH HHS P41 RR005351Wellcome Trust CC2127
6 · The paper itself

Abstract

Asparagine-linked protein glycosylation is among the most frequent modifications of proteins trafficking through the secretory pathway. These glycans are manufactured in an assembly line process to a common precursor that is then subject to individual modifications with different levels of complexity. An important biosynthetic modulator is the incorporation of

Identifiers

PMID41648446
PMCPMC12871145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.