Evidence map›Paper›PMID 41648444›Full record

ArticlebioRxiv : the preprint server for biology2026

A methylome-derived m

Zhiying Zhang, Yi Wu, Yan-Jiun Lee, Gianlucca G Nicastro, Arpita Chakravarti, Hui Fang, Daniela Taverner, Peter Weigele, L Aravind, Dinshaw J Patel and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiying ZhangStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5721-5828
Yi WuSchool of Biological Sciences, University of Southampton, SO17 1BJ Southampton, UK.
Yan-Jiun LeeResearch Department, New England Biolabs, Ipswich, MA 01938, USA.ORCID 0000-0001-7534-2302
Gianlucca G NicastroComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Arpita ChakravartiStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0009-3267-8450
Hui FangStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Daniela TavernerSchool of Biological Sciences, University of Southampton, SO17 1BJ Southampton, UK.
Peter WeigeleResearch Department, New England Biolabs, Ipswich, MA 01938, USA.ORCID 0000-0003-3696-4541
L AravindComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0003-0771-253X
Dinshaw J PatelStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Franklin L NobregaSchool of Biological Sciences, University of Southampton, SO17 1BJ Southampton, UK.ORCID 0000-0002-8238-1083

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Structure-Activity Based Mechanistic Insights into Cleavage Chemistry by Self-Cleaving Nucleolytic RibozymesR01GM145888 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PATEL, DINSHAW J · 2022 to 2025
$1.3M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM145888NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Bacteria must distinguish phage attack from normal homeostatic processes, yet the danger signals that trigger many defence systems remain unknown. Here, we show that a PUA-Calcineurin-CE-HAD module from

Indexed as

abortive infectionBacteriophage defenceCalcineurin-CEDam methylationDNA mimicdNTP depletionfilamentationHADm6-dAMPPUA

Identifiers

PMID41648444
PMCPMC12871103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.