Evidence map›Paper›PMID 41648437›Full record

ArticlebioRxiv : the preprint server for biology2026

Engineered probiotics that sequester arsenite in a mouse gastrointestinal system.

Nhu Nguyen, Miaomiao Wang, Sithembiso S Msibi, Vincenzo Kennedy, Fateme Esmailie, L Joseph Su, Lin Li, Clement T Y Chan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nhu NguyenDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Miaomiao WangDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Sithembiso S MsibiPeter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA.
Vincenzo KennedyDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Fateme EsmailieDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
L Joseph SuPeter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA.
Lin LiDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Clement T Y ChanDepartment of Biomedical Engineering, University of North Texas, Denton, TX, USA.

Funding

Development of Genetic Sensors and Circuits for Creating Novel Cellular BehaviorsR35GM142421 · NIGMS · UNIVERSITY OF NORTH TEXAS · PI CHAN, TSZ YAN CLEMENT · 2021 to 2025
$1.8M
New approach for identification pHFO networks to predict epileptogenesisR16NS131108 · NINDS · UNIVERSITY OF NORTH TEXAS · PI Lin Li · 2022 to 2026
$1.3M
Design and construct modular transcriptional repressors to facilitate the development of living diagnosticsR15GM135813 · NIGMS · UNIVERSITY OF NORTH TEXAS · PI CHAN, TSZ YAN CLEMENT · 2021 to 2021
$392k
NIGMS NIH HHS R15 GM135813NIGMS NIH HHS R35 GM142421NINDS NIH HHS R16 NS131108
6 · The paper itself

Abstract

Chronic exposure to inorganic arsenic remains a major global health concern, as arsenite is frequently present in contaminated food and drinking water and readily absorbed through the gastrointestinal (GI) tract. Once internalized, arsenite accumulates in tissues and contributes to long-term health effects, including cancer, organ dysfunction, and neurological disorders. Despite extensive efforts to reduce environmental contamination, there are currently no practical strategies to prevent dietary arsenite from entering the human body during digestion. Here, we report a synthetic biology-based approach that uses engineered probiotics to detect and sequester arsenite directly within the GI tract before systemic absorption occurs. We engineered

Identifiers

PMID41648437
PMCPMC12871311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.