Evidence map›Paper›PMID 41648432›Full record

ArticlebioRxiv : the preprint server for biology2026

Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading.

Farzad Yousefi, Eric A Simental, Yongming Du, Sam Whedon, Michael J Trnka, Daniel Darling, Sohpia Jia, Barbara Panning, Philip A Cole, Mario Halic and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Farzad YousefiDepartment of Microbiology and Immunology and the G.W. Hooper Foundation, University of California, San Francisco, CA, USA.
Eric A SimentalDepartment of Microbiology and Immunology and the G.W. Hooper Foundation, University of California, San Francisco, CA, USA.
Yongming DuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sam WhedonDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3745-5645
Michael J TrnkaDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Daniel DarlingDepartment of Microbiology and Immunology and the G.W. Hooper Foundation, University of California, San Francisco, CA, USA.
Sohpia JiaDepartment of Microbiology and Immunology and the G.W. Hooper Foundation, University of California, San Francisco, CA, USA.
Barbara PanningDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA USA.
Philip A ColeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Mario HalicDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bassem Al-SadyDepartment of Microbiology and Immunology and the G.W. Hooper Foundation, University of California, San Francisco, CA, USA.ORCID 0000-0002-8996-7941

Funding

Tracking how molecular machines propagate epigenetic information in time and spaceR35GM141888 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AL-SADY, BASSEM · 2021 to 2025
$2.3M
Chemical Approaches to Understanding Reversible Lysine ModificationsR35GM149229 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PHILIP A COLE · 2023 to 2026
$1.9M
OGT as a dosage sensorR01GM128431 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURLINGAME, ALMA L, PANNING, BARBARA · 2019 to 2022
$1.7M
Structural and functional studies of chromatin modifiersR01GM135599 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HALIC, MARIO · 2020 to 2023
$1.5M
Structural and Functional Studies of ChromatinR35GM158165 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Mario Halic · 2025 to 2026
$1.3M
Biochemically counteracting maladaptive functions of G9a/GLP in addictionR21DA062828 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bassem Al-Sady, Mario Halic · 2025 to 2026
$486k
NIDA NIH HHS R21 DA062828NIGMS NIH HHS R01 GM128431NIGMS NIH HHS R01 GM135599NIGMS NIH HHS R35 GM141888NIGMS NIH HHS R35 GM149229NIGMS NIH HHS R35 GM158165
6 · The paper itself

Abstract

Repressive histone methyltransferases carry a catalytic ("write") domain and a separate domain specialized for recognizing ("reading") the reaction product. This read-write configuration acts as a positive feedback mechanism for epigenetic maintenance and the growth of repressive chromatin domains. Feedback exhibits as catalytic stimulation and is understood to act towards a proximal (

Identifiers

PMID41648432
PMCPMC12871594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.