Evidence map›Paper›PMID 41648430›Full record

ArticlebioRxiv : the preprint server for biology2026

Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.

Drew W Grant, Shengjiang Tan, Dylan E Ramage, Mamie Z Li, Ying Di, Iva A Tchasovnikarova, Michael P Weekes, Stephen J Elledge, Alan J Warren, Richard T Timms

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Drew W GrantCambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.ORCID 0009-0000-0190-3082
Shengjiang TanCambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.ORCID 0009-0007-0186-3624
Dylan E RamageCambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.ORCID 0009-0004-4596-9509
Mamie Z LiDepartment of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur Boston, MA 02115, USA.
Ying DiCambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.
Iva A TchasovnikarovaThe Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.
Michael P WeekesCambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.ORCID 0000-0003-3196-5545
Stephen J ElledgeDepartment of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur Boston, MA 02115, USA.
Alan J WarrenCambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.ORCID 0000-0001-9277-4553
Richard T TimmsCambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.ORCID 0000-0001-7275-597X

Funding

Ubiquitin Mediated Proteolysis and Cell Cycle ControlR01AG011085 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JEFFREY W HARPER · 1993 to 2026
$10.9M
NIA NIH HHS R01 AG011085Wellcome Trust
6 · The paper itself

Abstract

Many E3 ubiquitin ligases recognize cognate degron motifs located at protein termini, but the paucity of

Identifiers

PMID41648430
PMCPMC12871134

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.