Evidence map›Paper›PMID 41648420›Full record

ArticlebioRxiv : the preprint server for biology2026

Reconstructing a Missing Link of HIV-1 Assembly: HIV-1 Envelope-Matrix Interactions in a Native Viral Context.

Jacob T Croft, Hung N Do, Daniel P Leaman, Klaus N Lovendahl, Pooja Ralli-Jain, Katelyn J Chase, Cynthia A Derdeyn, Michael B Zwick, S Gnanakaran, Kelly K Lee

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob T CroftDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8964-3699
Hung N DoTheoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA 87545.ORCID 0000-0002-6497-4096
Daniel P LeamanDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-8490-1126
Klaus N LovendahlDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3871-3570
Pooja Ralli-JainDepartment of Laboratory Medicine & Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA.
Katelyn J ChaseDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2715-382X
Cynthia A DerdeynDepartment of Laboratory Medicine & Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA.ORCID 0000-0002-1220-513X
Michael B ZwickDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-0885-2502
S GnanakaranTheoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA 87545.ORCID 0000-0002-9368-3044
Kelly K LeeDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5577-9873

Funding

Project 3 - Dynamics of latent HIV-1 reservoirs: High resolution antigenic mapping and strategies to block reboundU54AI170752 · NIAID · DUKE UNIVERSITY · PI Priyamvada Acharya · 2022 to 2026
$32.0M
Structural and dynamic traits underlying phenotypic variation in HIV-1 EnvR01AI140868 · NIAID · UNIVERSITY OF WASHINGTON · PI Kelly Keisen Lee · 2019 to 2026
$5.3M
Interplay of the HIV-1 Env cytoplasmic tail, Gag-MA, and membrane: resolving molecular detail and blocking assemblyR01AI179697 · NIAID · UNIVERSITY OF WASHINGTON · PI DERDEYN, CYNTHIA ANN, GNANAKARAN, SANDRASEGARAM · 2023 to 2025
$3.1M
Exploiting glycan holes and sequence diversity of naturally occurring HIV envelope towards the design of vaccine immunogen panels for induction of neutralization breadthR01AI186650 · NIAID · UNIVERSITY OF WASHINGTON · PI Cynthia Ann Derdeyn, Sandrasegaram Gnanakaran · 2024 to 2026
$2.3M
Gates Foundation INV-010646NIAID NIH HHS R01 AI140868NIAID NIH HHS R01 AI179697NIAID NIH HHS R01 AI186650NIAID NIH HHS U54 AI170752
6 · The paper itself

Abstract

The envelope surface glycoprotein (Env) on HIV-1 drives cell entry and genome delivery through its receptor binding and membrane fusion activities. Incorporation of Env onto assembling virions is governed by its cytoplasmic tail (Env-CT) and the matrix (MA) domain of the PR55

Indexed as

cryo-electron tomographycytoplasmic tailEnvGagglycoproteinHIV-1matrix proteinmaturationmembranemolecular dynamicsprotein dynamicsretrovirussubtomogram averagingvirus structure

Identifiers

PMID41648420
PMCPMC12871272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.