Evidence map›Paper›PMID 41648415›Full record

ArticlebioRxiv : the preprint server for biology2026

Evolutionary Divergence of mTOR-mediated Transcriptional Regulation Between

Yevgeniy Raynes, John C Santiago, Faye A Lemieux, David M Rand

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yevgeniy RaynesDepartment of Ecology, Evolution, and Organismal Biology, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-1608-9479
John C SantiagoDepartment of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI 02912, USA.
Faye A LemieuxDepartment of Ecology, Evolution, and Organismal Biology, Brown University, Providence, RI 02912, USA.
David M RandDepartment of Ecology, Evolution, and Organismal Biology, Brown University, Providence, RI 02912, USA.ORCID 0000-0001-6817-3459

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2016 to 2025
$22.6M
Nuclear-Mitochondrial Fitness Interactions in DrosophilaR01GM067862 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2004 to 2020
$5.1M
Mitonuclear genetics of complex traits in DrosophilaR35GM139607 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2021 to 2025
$1.9M
Mitochondrial genes and TOR signaling in DrosophilaF31GM117851 · NIGMS · BROWN UNIVERSITY · PI SANTIAGO, JOHN C. · 2016 to 2018
$128k
NIGMS NIH HHS F31 GM117851NIGMS NIH HHS P20 GM109035NIGMS NIH HHS R01 GM067862NIGMS NIH HHS R35 GM139607
6 · The paper itself

Abstract

Evolutionary divergence in gene regulation is a major source of phenotypic novelty, yet understanding how deeply conserved, pleiotropic signaling pathways evolve under selective constraint while maintaining essential cellular functions remains an important challenge. Here, we investigate the evolutionary divergence in transcriptional regulation mediated by the mechanistic target of rapamycin (mTOR) pathway in two related species,

Indexed as

Drosophilaevolutionary modularitymTOR signalingRapamycinRNA-seqtranscriptional divergence

Identifiers

PMID41648415
PMCPMC12871165

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.