Evidence map›Paper›PMID 41648412›Full record

ArticlebioRxiv : the preprint server for biology2026

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex.

Anupama Rai, Artemis Iatrou, Irais Valenzuela Arzeta, Alexandra L Bartlett, Jane Banahan, Vedant Desai, Lorena Pantano, Isabel Castanho, Pourya Naderi Yeganeh, Athanasios Ploumakis and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Anupama RaiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Artemis IatrouDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Irais Valenzuela ArzetaDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Alexandra L BartlettHarvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.
Jane BanahanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Vedant DesaiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Lorena PantanoHarvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.
Isabel CastanhoDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pourya Naderi YeganehDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Athanasios PloumakisDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Shuoshuo WangDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Antonella Arruda de AmaralDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Nikolaos KalavrosDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Sheethal Umesh NagalakshmiSpatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Peter TsvetkovDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-7577-2342
Sabina BerrettaDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Isaac H SolomonDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Winston HideDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Ioannis S VlachosDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Frank J SlackDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Recep OzdemirDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Shannan Ho SuiHarvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.
Nikolaos P DaskalakisDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.ORCID 0000-0003-1660-9112
Maria MavrikakiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI Irene M. Ghobrial · 1985 to 2026
$330.6M
Non-coding RNAs in resilience to Alzheimer’s DiseaseR01AG082093 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Winston Alexander Hide, Doo Yeon Kim · 2023 to 2026
$3.4M
Molecular mechanisms of aging and accelerated aging in the human brainR01AG079799 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Maria Mavrikaki · 2023 to 2026
$2.7M
Next steps for PTSD genomics: from loci to functionR01MH133268 · NIMH · MCLEAN HOSPITAL · PI Nikolaos Daskalakis, Caroline M Nievergelt · 2024 to 2026
$2.5M
NCI NIH HHS P30 CA006516NIA NIH HHS R01 AG079799NIA NIH HHS R01 AG082093NIMH NIH HHS R01 MH133268
6 · The paper itself

Abstract

The human prefrontal cortex (PFC), whose laminar organization is essential for cognitive function, is among the first regions to show age-related functional decline

Identifiers

PMID41648412
PMCPMC12871360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.