In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Juan Ortiz-MateuDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0000-0003-3597-4481 Marina Rius-SalvadorDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0009-0008-1530-1216 Anna PavlovaSchool of Physics, School of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-6527-944X Josep Alonso-RomeroDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.
José M Acosta-CáceresDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0000-0003-0958-7226 María Jesús García-MurriaDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0000-0002-8396-0335 J Mark SkehelProteomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.ORCID 0000-0002-2432-0901 James C GumbartSchool of Physics, School of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-1510-7842 Gunnar von HeijneDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-4490-8569 Manuel Mateo Sánchez-Del PinoDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0000-0001-9696-7600 Luis Martínez-GilDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0000-0002-9076-7760 Ismael MingarroDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Burjassot E-46100, Spain.ORCID 0000-0002-1910-1229 Funding
Elucidating the mechanisms of protein secretion across the outer membrane by bacterial autotransportersR01GM148586 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI James C. Gumbart · 2023 to 2026
$1.8MNIGMS NIH HHS R01 GM148586Wellcome Trust CC1063Wellcome Trust CC2166
6 · The paper itselfAbstract
Viral protein biogenesis underpins every viral life cycle stage, and elucidating these processes could reveal fundamental principles of virus-host interaction, and vulnerabilities amenable to therapeutic targeting. Here we apply biophysical, molecular, and cell biology techniques to investigate the insertion, folding, and oligomerization of the SARS-CoV-2 M protein. We describe the sequential co-translational insertion of the hydrophobic core, and demonstrate that the cytosolic C-terminal domain undergoes slower adoption of its tertiary structure. Additionally, we characterize how the transmembrane domain bundle facilitates M-protein oligomerization. Our results reveal a hydrophobic residue cluster that is essential for protein folding and co-translational dimerization. Additionally, we identify the cellular machinery responsible for targeting and inserting the M protein into the ER membrane, and chaperones and cofactors that may contribute to proper folding.
Identifiers
PMID41648391
PMCPMC12871657
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