Evidence map›Paper›PMID 41648379›Full record

ArticlebioRxiv : the preprint server for biology2026

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.

Harald Hartweger, Chiara Ruprecht, Kai-Hui Yao, Philippe Laffont, Gabriella Lima Dos Reis, Pengcheng Zhou, Thomas Hägglöf, Laurine Binet, Maximilian Loewe, Jun P Hong and 19 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Harald HartwegerLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0000-0002-1118-1818
Chiara RuprechtLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.
Kai-Hui YaoLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.
Philippe LaffontLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0009-0008-6977-7009
Gabriella Lima Dos ReisLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0000-0001-7511-1379
Pengcheng ZhouLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.
Thomas HägglöfLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0000-0002-7751-0928
Laurine BinetLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0009-0005-3260-8891
Maximilian LoeweLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0000-0003-2935-3750
Jun P HongLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.
Tianli XiaoDepartment of Immunobiology, Yale School of Medicine; New Haven, Connecticut, USA.
Esen SefikDepartment of Immunobiology, Yale School of Medicine; New Haven, Connecticut, USA.ORCID 0000-0002-6807-3498
Brianna HernandezLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.
Anna GazumyanLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.
Mila JankovicLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0000-0001-9696-5234
Michael S SeamanCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School; Boston, MA, USA.
Giulia CostaVector Biology Unit, Max Planck Institute for Infection Biology; Berlin, Germany.
Sean A NelsonDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.ORCID 0000-0002-9000-3496
Jordan ClarkDepartment of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA.
Sachie KanataniJohns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute; Baltimore, MD, USA.ORCID 0000-0002-7072-0447
Patrick C WilsonDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine; New York, NY, USA.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA.
Elena A LevashinaVector Biology Unit, Max Planck Institute for Infection Biology; Berlin, Germany.ORCID 0000-0003-4605-906X
Jean-Philippe JulienProgram in Molecular Medicine, The Hospital for Sick Children Research Institute; Toronto, Ontario, Canada.ORCID 0000-0001-7602-3995
Hedda WardemannB Cell Immunology, German Cancer Research Center (DKFZ); Heidelberg, Germany.ORCID 0000-0003-3921-5933
Photini SinnisJohns Hopkins School of Public Health and Johns Hopkins Malaria Research Institute; Baltimore, MD, USA.ORCID 0000-0003-2954-7547
Leonidas StamatatosVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center; Seattle, WA, USA.ORCID 0000-0002-1106-7097
Richard A FlavellDepartment of Immunobiology, Yale School of Medicine; New Haven, Connecticut, USA.ORCID 0000-0003-4461-0778
Michel C NussenzweigLaboratory of Molecular Immunology, Rockefeller University; New York, NY, USA.ORCID 0000-0003-0592-8564

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
Stuctural basis of bNab activityP01AI100148 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Pamela J Bjorkman · 2013 to 2026
$43.3M
INSPIRE: Innovative Strategies for Personalized Immunotherapies and Reservoir EradicationUM1AI191237 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2025 to 2026
$5.9M
Immunity and Infectious DiseaseT32AI070084 · NIAID · ROCKEFELLER UNIVERSITY · PI Michel C Nussenzweig · 2008 to 2026
$3.3M
The Skin Phase of Malaria Infection (Sharon Patray Diversity Supplement)R01AI132359 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SINNIS, PHOTINI · 2017 to 2021
$2.7M
Gates Foundation INV-002777Gates Foundation INV-008866Gates Foundation INV-036842NIAID NIH HHS P01 AI100148NIAID NIH HHS R01 AI132359NIAID NIH HHS T32 AI070084NIAID NIH HHS UM1 AI144462NIAID NIH HHS UM1 AI191237
6 · The paper itself

Abstract

Long-term

Identifiers

PMID41648379
PMCPMC12871283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.