ArticlebioRxiv : the preprint server for biology2026
Genomic and phenotypic diversification of
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Opportunistic bacterial pathogens often encounter strong selective pressures outside their hosts, yet the evolutionary consequences of long-term predator exposure remain poorly understood. Here, we used experimental evolution to examine how sustained interaction with a eukaryotic predator shapes genomic adaptation, phenotypic diversification, and virulence-associated traits in Significance: Many bacterial pathogens spend much of their evolutionary history outside hosts, where they face intense ecological pressures such as predation. How these pressures shape pathogen evolution and disease potential remains unclear. Using experimental evolution, genomics, and phenotypic analyses, we show that prolonged exposure to a eukaryotic predator drives predictable genetic and phenotypic changes in the opportunistic pathogen
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