Evidence map›Paper›PMID 41648316›Full record

ArticlebioRxiv : the preprint server for biology2026

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis.

Fabian Stei, Erin F McCaffrey, Björn Zessin, Jonathan Pioch, Stefan Simm, Beate Stubbe, Ralf Ewert, Frank Verreck, Bianca E Schneider, Anca Dorhoi and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Fabian SteiInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald - Isle of Riems, Germany.
Erin F McCaffreySpatial Immunology Unit, T-Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Björn ZessinInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald - Isle of Riems, Germany.
Jonathan PiochInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald - Isle of Riems, Germany.
Stefan SimmInstitute of Bioanalytics, University of Applied Sciences Coburg, Germany.
Beate StubbeInternal Medicine B, Pneumology, University Hospital Greifswald, Greifswald, Germany.
Ralf EwertInternal Medicine B, Pneumology, University Hospital Greifswald, Greifswald, Germany.
Frank VerreckBiomedical Primate Research Centre, Rijswijk, The Netherlands.
Bianca E SchneiderPriority Area Infections, Research Center Borstel-Leibniz Lung Center, Germany.
Anca DorhoiInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald - Isle of Riems, Germany.
Bryan D BrysonRagon Institute of MGH, Harvard, and MIT, Cambridge, USA.ORCID 0000-0003-1716-6712
Björn CorleisInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald - Isle of Riems, Germany.

Funding

Dynamics of the cellular and molecular architecture of human pulmonary TB granulomasR01AI166313 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$3.2M
High-dimensional characterization of phagosome composition, control and phagocytic receptor redundancyR35GM142900 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BRYSON, BRYAN DAVID · 2021 to 2025
$2.1M
NIAID NIH HHS R01 AI166313NIGMS NIH HHS R35 GM142900
6 · The paper itself

Abstract

Rationale: Tuberculosis vaccines aim to elicit protective immunity, with IFNγ-producing CD4 Objective: To define the relevance of IFNγ-induced iNOS activity in humans and other natural host of virulent mycobacterial species. Methods: We systematically compared IFNγ-induced effector responses in Measurements and Main Results: Single-cell transcriptomic reanalysis revealed minimal Conclusion: IFNγ signaling is uncoupled from iNOS induction in primate myeloid cells and epithelial compartments represent dominant sources of iNOS in human tuberculosis. These findings, challenge murine macrophage-centric paradigms and IFNγ-based correlates used in TB vaccine development and central to pathophysiology of tuberculosis and other pneumonias.

Identifiers

PMID41648316
PMCPMC12871230

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.