Evidence map›Paper›PMID 41648311›Full record

ArticlebioRxiv : the preprint server for biology2026

Ribosomal Protein bL27 Protects Translating Ribosomes from tmRNA-SmpB.

Divyasorubini Seerpatham, George Wanes, Chathuri Pathirage, Mynthia Cabrera, Edu Usoro, Kristin Koutmou, Christine M Dunham, Paul C Whitford, Kenneth C Keiler

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Divyasorubini SeerpathamDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX.
George WanesCenter for Theoretical Biological Physics, Northeastern University, Boston, MA.
Chathuri PathirageUniversity of Michigan, Ann Arbor, MI.
Mynthia CabreraDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA.
Edu UsoroDepartment of Chemistry, Emory University, Atlanta, GA.
Kristin KoutmouUniversity of Michigan, Ann Arbor, MI.
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, GA.
Paul C WhitfordCenter for Theoretical Biological Physics, Northeastern University, Boston, MA.
Kenneth C KeilerDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX.ORCID 0000-0001-8753-335X

Funding

Mechanisms of translational controlR35GM128836 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristin S Koutmou · 2018 to 2026
$3.2M
Elucidating the mechanisms that enable translation in bacterial and eukaryotic ribosomesR35GM153502 · NIGMS · NORTHEASTERN UNIVERSITY · PI Paul Charles Whitford · 2024 to 2026
$1.3M
Ribosome regulation, inhibition, and quality control mechanismsR35GM156629 · NIGMS · EMORY UNIVERSITY · PI Christine M Dunham · 2025 to 2026
$899k
NIGMS NIH HHS R35 GM128836NIGMS NIH HHS R35 GM153502NIGMS NIH HHS R35 GM156629
6 · The paper itself

Abstract

Bacterial ribosomal protein bL27 is universally conserved and its amino terminus is adjacent to the peptidyl transfer center, yet its role in translation remains unclear. Combining genetics, biochemistry and molecular dynamics, we show that bL27 has an unexpected role in preventing

Identifiers

PMID41648311
PMCPMC12871816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.