Evidence map›Paper›PMID 41648303›Full record

ArticlebioRxiv : the preprint server for biology2026

Visualization of the complete primosome reveals the structural mechanisms governing DNA replication restart.

Peter L Ducos, Alexander T Duckworth, Kenneth A Satyshur, James L Keck, Timothy Grant

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Peter L DucosJohn and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.ORCID 0000-0002-9172-1238
Alexander T DuckworthJohn and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.ORCID 0000-0002-7713-4117
Kenneth A SatyshurDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-9371-2493
James L KeckDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-5961-0220
Timothy GrantJohn and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, USA.ORCID 0000-0002-4855-8703

Funding

Structure and Function of the Bacterial PrimosomeR01GM098885 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI James L Keck · 2012 to 2026
$4.0M
NIGMS NIH HHS R01 GM098885
6 · The paper itself

Abstract

Replication restart pathways reinitiate DNA replication processes following their premature termination. In

Identifiers

PMID41648303
PMCPMC12871339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.