Evidence map›Paper›PMID 41648283›Full record

ArticlebioRxiv : the preprint server for biology2026

First inhibitor of a bacterial two-partner secretion system.

Alfred Hartojo, Laurence Don Wai Luu, Lachlan Adamson, Kyra Majors, Ashleigh S Paparella, Peggy A Cotter, Richard M Johnson, Matthew Thomas Doyle

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alfred HartojoSydney Infectious Disease Institute, The University of Sydney, Darlington, New South Wales, Australia.ORCID 0009-0002-3920-7589
Laurence Don Wai LuuSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.ORCID 0000-0003-2516-2121
Lachlan AdamsonSydney Infectious Disease Institute, The University of Sydney, Darlington, New South Wales, Australia.ORCID 0000-0002-9862-9557
Kyra MajorsDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-4489-7636
Ashleigh S PaparellaSydney Infectious Disease Institute, The University of Sydney, Darlington, New South Wales, Australia.ORCID 0000-0003-1816-1286
Peggy A CotterDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3726-3990
Richard M JohnsonDepartment of Microbiology and Immunology, East Carolina University, Brody School of Medicine, Greenville, North Carolina, USA.ORCID 0000-0002-0355-889X
Matthew Thomas DoyleSydney Infectious Disease Institute, The University of Sydney, Darlington, New South Wales, Australia.ORCID 0000-0002-1876-1209

Funding

Uncovering the two-partner secretion mechanism and novel antimicrobialsR21AI180112 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A, DOYLE, MATTHEW THOMAS · 2024 to 2025
$371k
NIAID NIH HHS R21 AI180112
6 · The paper itself

Abstract

Two-partner secretion system transporter proteins (TpsB) are widely conserved across Gram-negative pathogens. TpsB family proteins secrete exoprotein virulence factors that perform a myriad of functions such as adhesion and immune modulation. Despite their incredible importance in bacterial infectious disease, TpsB inhibitors have not yet been discovered. Here, we describe a potent inhibitor of FhaC, a TpsB protein produced by

Identifiers

PMID41648283
PMCPMC12871346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.