Evidence map›Paper›PMID 41648238›Full record

ArticlebioRxiv : the preprint server for biology2026

Chromosome 3p deletion leads to extensive genomic alterations in diverse cancers and confers synthetic lethality in uveal melanoma.

Mitchell C Cutler, Porter B Howland, Miroslav Hejna, Jun S Song

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mitchell C CutlerDepartment of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-8682-8305
Porter B HowlandDepartment of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0009-0008-1197-8983
Miroslav HejnaDepartment of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-3613-1796
Jun S SongDepartment of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-0422-2175

Funding

Predicting Transcriptional and Epigenetic Networks in Cancer from Sequencing DataR01CA163336 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Jun S Song · 2012 to 2026
$4.4M
NCI NIH HHS R01 CA163336
6 · The paper itself

Abstract

Chromosome 3p (chr3p) is frequently deleted in multiple cancers, indicating the presence of shared tumor suppressors. Analysis of genomic alterations in 33 different cancer types implicates the deletion or deleterious mutations of SET-domain-containing 2 (

Indexed as

cancer genome evolutionfragmentation of chromosomesisochromosomessynthetic lethalityUveal melanoma

Identifiers

PMID41648238
PMCPMC12871722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.