Evidence map›Paper›PMID 41648235›Full record

ArticlebioRxiv : the preprint server for biology2026

Aging macaques bridge the translational gap in perivascular space biology.

William A Liguore, Daniel L Schwartz, Juan Piantino, Avanthika Rajendran, Greg Jensen, Joshua A Karpf, Mykyta M Chernov, Randall L Woltjer, Steven G Kohama, Lisa C Silbert and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

William A LiguoreOregon National Primate Research Center.ORCID 0000-0002-6853-1882
Daniel L SchwartzOregon Health & Science University.
Juan PiantinoDivision of Child Neurology, Department of Pediatrics, Oregon Health and Science University.ORCID 0000-0002-8861-5709
Avanthika RajendranReed College.
Greg JensenReed College.ORCID 0000-0001-5050-4360
Joshua A KarpfOregon National Primate Research Center.ORCID 0000-0001-6672-3445
Mykyta M ChernovOregon National Primate Research Center.ORCID 0000-0002-5301-6968
Randall L WoltjerOregon Health & Science University.ORCID 0000-0003-0755-9846
Steven G KohamaOregon National Primate Research Center.ORCID 0000-0003-4258-4377
Lisa C SilbertOregon Health & Science University.ORCID 0000-0002-4525-0068
Alison R WeissOregon National Primate Research Center.ORCID 0000-0002-1821-8193

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
Understanding the effect of post-concussive sleep disruption on glymphatic function in collegiate athletesR01HL173372 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Juan Andres Piantino · 2025 to 2026
$1.5M
Biomarkers of Inflammation, Neurodegeneration and Age-Associated Cognitive ImpairmentK01AG078407 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WEISS, ALISON RUTH · 2022 to 2024
$579k
Early Identification of Neurodevelopmental Disorders with in utero MRIF31MH138114 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Joshua Karpf · 2025 to 2026
$103k
NHLBI NIH HHS R01 HL173372NIA NIH HHS K01 AG078407NIA NIH HHS P30 AG066518NIH HHS P51 OD011092NIMH NIH HHS F31 MH138114
6 · The paper itself

Abstract

The prevalence of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association between age and PVS burden, with an anatomical distribution paralleling that of humans. Preliminary

Identifiers

PMID41648235
PMCPMC12871328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.