Evidence map›Paper›PMID 41648217›Full record

ArticlebioRxiv : the preprint server for biology2026

Biosynthesis of 14-membered cyclopeptide alkaloids via non-heme-iron- and 2-oxoglutarate-dependent oxidative decarboxylation.

Jordan Hungerford, Lisa S Mydy, Xiaofeng Wang, Lorena Mendoza-Perez, Derrick A Ousley, Khadija Shafiq, Kali M McDonough, Wenjie Li, Gabrielle May, Desnor N Chigumba and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jordan HungerfordDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Lisa S MydyDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiaofeng WangDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Lorena Mendoza-PerezDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Derrick A OusleyDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Khadija ShafiqDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Kali M McDonoughDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Wenjie LiDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Gabrielle MayDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Desnor N ChigumbaDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Shengrui YaoDepartment of Plant and Environmental Sciences, Sustainable Agriculture Science Center at Alcalde, New Mexico State University, Alcalde, NM, 87511, USA.
Roland D KerstenDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-5811-7330

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Discovery, Biosynthesis and Engineering of Side-Chain-Macrocyclic Plant PeptidesR35GM146934 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Roland David Kersten · 2022 to 2026
$1.8M
Mechanistic Investigation of Copper-Dependent Peptide Cyclases for Macrocycle EngineeringF32GM146395 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYDY, LISA SUSANNAH · 2022 to 2023
$152k
Biosynthetic Development and Diversification of Moroidin Peptides for Cancer ApplicationsF31GM155959 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAFIQ, KHADIJA · 2024 to 2025
$49k
NIGMS NIH HHS F31 GM155959NIGMS NIH HHS F32 GM146395NIGMS NIH HHS R35 GM146934NIGMS NIH HHS T32 GM140223
6 · The paper itself

Abstract

Cyclopeptide alkaloids are an expanding class of plant peptide natural products defined by a macrocyclic ether-crosslink via a tyrosine-derived phenol. Classical cyclopeptide alkaloids are characterized by strained 13- to 15-membered cyclophanes and terminal modifications such as

Indexed as

burpitidecyclopeptide alkaloidnatural productsRiPP

Identifiers

PMID41648217
PMCPMC12871766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.