Evidence map›Paper›PMID 41648211›Full record

ArticlebioRxiv : the preprint server for biology2026

Neonatal Enteric Infection Disrupts the Microbiota-Gut-Brain Axis Through Pattern Recognition Receptors and Altered Neuroimmune Signaling.

Jungjae Park, Olivia Orahood, Maithili Banginwar, Amy Andrade, Gatha Pore, Kristina Sanchez, Michael Cremin, Jelissa Reynoso-Garcia, Sarah Lee, Ingrid Brust-Mascher and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Jungjae ParkDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Olivia OrahoodDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Maithili BanginwarDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Amy AndradeDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Gatha PoreDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Kristina SanchezDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Michael CreminDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Jelissa Reynoso-GarciaDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Sarah LeeDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Ingrid Brust-MascherDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Mariana BarbozaDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Carlito B LebrillaDepartment of Chemistry, University of California Davis, Davis, California, USA.
Taeseon WooSchool of Dentistry, NYU, New York, NY, USA.
Kara G MargolisSchool of Dentistry, NYU, New York, NY, USA.
Colin ReardonDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Mélanie G GareauDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID 0000-0001-6008-6975

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
The microbiota-gut-brain axis in Alzheimers diseaseR01AT009365 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GAREAU, MELANIE G · 2017 to 2021
$2.2M
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brainR01DK126644 · NIDDK · NEW YORK UNIVERSITY · PI MARGOLIS, KARA GROSS · 2021 to 2024
$1.9M
Early microbial colonization and development of the microbiota-gut-brain axisR21MH108154 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GAREAU, MELANIE G · 2015 to 2016
$542k
NCCIH NIH HHS R01 AT009365NCI NIH HHS P30 CA093373NIAID NIH HHS T32 AI060555NIDDK NIH HHS R01 DK126644NIMH NIH HHS R21 MH108154NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

Early-life enteric infection can have long-lasting effects on the microbiota-gut-brain (MGB) axis. Using a neonatal Enteropathogenic

Indexed as

Enteric nervous systemEnteric pathogensGut-BrainMuropeptidePattern recognition receptorsProbiotics

Identifiers

PMID41648211
PMCPMC12871257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.