Evidence map›Paper›PMID 41648186›Full record

ArticlebioRxiv : the preprint server for biology2026

Versatile high-speed volumetric imaging from microscopic to macroscopic scale by self-adaptive oblique plane microscopy.

Dominique Meyer, Grant Kroeschell, Xiankun Lu, Linh Hoang, Haochen Wang, Shuying Li, Yu Kang T Xu, Lei Tian, Jeff S Mumm, Dwight E Bergles and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominique MeyerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore MD, 21231.ORCID 0000-0002-3240-5227
Grant KroeschellCross Disciplinary Graduate Program in Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0009-0004-0220-6886
Xiankun LuDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore MD, 21231.ORCID 0009-0006-8768-8718
Linh HoangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore MD, 21231.ORCID 0000-0002-7764-3915
Haochen WangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore MD, 21231.ORCID 0009-0001-8835-369X
Shuying LiDepartment of Chemical, Paper and Biomedical Engineering, Miami University-Oxford, Oxford OH, 45045.
Yu Kang T XuDepartment of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore MD, 21231.ORCID 0000-0002-1016-0919
Lei TianDepartment of Electric and Computer Engineering, Boston University, Boston MA, 02113.ORCID 0000-0002-1316-4456
Jeff S MummDepartment of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore MD, 21231.ORCID 0000-0002-2575-287X
Dwight E BerglesDepartment of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore MD, 21231.ORCID 0000-0002-7133-7378
Ji YiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore MD, 21231.ORCID 0000-0001-6583-7192

Funding

The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
Mechanisms by which effector T cells modulate endogenous remyelinationR37NS041435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CALABRESI, PETER A · 2013 to 2019
$3.0M
Aging dependent transformation of oligodendrocyte precursor cellsR01AG072305 · NIA · JOHNS HOPKINS UNIVERSITY · PI BERGLES, DWIGHT E, GOFF, LOYAL ANDREW · 2021 to 2025
$2.0M
Mesoscopic microscopy for ultra-high speed and large-scale volumetric brain imagingR01EB034272 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 2023 to 2026
$1.9M
NIA NIH HHS R01 AG072305NIBIB NIH HHS R01 EB034272NINDS NIH HHS R01 NS041435NINDS NIH HHS R37 NS041435
6 · The paper itself

Abstract

There is an increasing need for large-scale high-speed volumetric recording in complex multi-cellular model systems to define dynamic processes. Oblique plane microscopy (OPM) provides a solution that features oblique illumination, rapid optical scanning, and remote focusing to achieve real-time 4D microscopy. OPM implements light sheet imaging via a single primary objective lens, making the entire space below the objective accessible for large specimens, such as living mouse brain. Yet it is challenging to adopt OPM beyond a microscopic scale (

Identifiers

PMID41648186
PMCPMC12871264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.