Evidence map›Paper›PMID 41648183›Full record

ArticlebioRxiv : the preprint server for biology2026

Ventral pallidal perineuronal nets regulate opioid relapse.

Margareth Nogueira, Giuseppe Giannotti, Carley N Miller, Savanna D Guaderrama, Nathaniel P Kregar, Brandi Wiedmeyer, Nicholas Fayette, Jasper A Heinsbroek

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Margareth NogueiraDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35242, USA.ORCID 0000-0002-5735-0576
Giuseppe GiannottiDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-0629-4882
Carley N MillerDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8746-7206
Savanna D GuaderramaDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Nathaniel P KregarDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35242, USA.ORCID 0000-0002-4537-6904
Brandi WiedmeyerDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-4938-4493
Nicholas FayetteDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8141-5368
Jasper A HeinsbroekDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35242, USA.ORCID 0000-0003-4641-6899

Funding

Target Specificity of Tabernanthalog Treatment in Opioid Use DisorderR01DA056660 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jasper Heinsbroek, JAMIE PETERS · 2022 to 2026
$2.6M
Dissecting Ventral Pallidal Subcircuit Contributions to Drug Seeking in AddictionDP5OD026407 · OD · UNIVERSITY OF COLORADO DENVER · PI HEINSBROEK, JASPER · 2019 to 2023
$1.9M
NIDA NIH HHS R01 DA056660NIH HHS DP5 OD026407
6 · The paper itself

Abstract

Opioid use disorder remains a major health challenge worldwide. Neuronal activity in the ventral pallidum (VP) regulates opioid reward and relapse to opioid seeking but the underlying cellular mechanisms remain largely unknown. A sizable population of VP neurons previously linked to drug relapse expresses the calcium binding protein parvalbumin (VP

Indexed as

heroinopioid use disorderparvalbumin neuronsperineural netsVentral pallidum

Identifiers

PMID41648183
PMCPMC12871611

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.