ArticlebioRxiv : the preprint server for biology2026
Federated single-cell QTL meta-analysis reveals novel disease mechanisms.
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Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
59 authors.
Daniel KaptijnDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0009-0008-7529-2040
Lieke MichielsenDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-4615-1309
Drew NeavinTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Aida Ripoll-CladellasLife Sciences Department, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain.
José Alquicira-HernándezTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Maryna KorshevniukDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0009-0007-9943-8895
Jimmy Tsz Hang LeeWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Roy OelenDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0002-5026-6531
Martijn VochtelooDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0002-6385-0550
Robert WarmerdamDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0001-8691-0053
Yoshinari AndoLaboratory for Genome Information Analysis, RIKEN Center for Integrative Medical Sciences, Japan.
Maria BanUniversity of Cambridge, Department of Clinical Neurosciences, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Odmaa BayaraaBiology Program, New York University Abu Dhabi, United Arab Emirates.
Marijn BergDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Irene van BloklandDepartment of Genetics, University of Groningen, University Medical Center Groningen.
Daniel ConsidineWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0009-0008-7769-2195
Mame M DiengBiology Program, New York University Abu Dhabi, United Arab Emirates.
Ryuya EdahiroDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.
M Grace GordonBiological and Medical Informatics Graduate Program, University of California San Francisco, San Francisco, USA.
Hilde E GrootDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-8265-3085
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-2713-686X
Matthias HeinigInstitute of Computational Biology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-5612-1720
Chung-Chau HonLaboratory for Genome Information Analysis, RIKEN Center for Integrative Medical Sciences, Japan.
Youssef IdaghdourBiology Program, New York University Abu Dhabi, United Arab Emirates.
Pooja KathailDepartment of Electrical Engineering and Computer Science, Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Niek de KleinWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Wenchao LiCentre for Individualised Infection Medicine (CiiM) & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
Yang LiCentre for Individualised Infection Medicine (CiiM) & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
Corinna LosertInstitute of Computational Biology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-5997-4702
Vinu ManikandaBiology Program, New York University Abu Dhabi, United Arab Emirates.
Jonathan MoodyLaboratory for Genome Information Analysis, RIKEN Center for Integrative Medical Sciences, Japan.
Haroon NaeemSidra Medicine, Doha, Qatar.
Younes MokrabSidra Medicine, Doha, Qatar.
Martijn C NawijnDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mihai NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands.
Jelmer NiewoldDepartment of Genetics, University of Groningen, University Medical Center Groningen.
Yukinori OkadaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Japan.
Stephen SawcerUniversity of Cambridge, Department of Clinical Neurosciences, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Issiaka SoulamaInstitut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.
Oliver StegleWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Yakov TsepilovWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-4931-6052
Woong-Yang ParkSamsung Genome Institute, Samsung Medical Center, Seoul, Korea.
Deepa RajagopalanA*STAR Genome Institute of Singapore, Singapore.
Tala ShahinBiology Program, New York University Abu Dhabi, United Arab Emirates.
Jay W ShinA*STAR Genome Institute of Singapore, Singapore.
Gosia TrynkaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Urmo VõsaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Harm-Jan WestraDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0001-7038-567X
Seyhan YazarTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Jimmie YeUCSF Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6560-3783
Zhenhua ZhangCentre for Individualised Infection Medicine (CiiM) & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.ORCID 0000-0002-1781-7127
eQTLGen consortium
Martin HembergThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, USA.
Ahmed MahfouzDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-8601-2149
Marta MeléLife Sciences Department, Barcelona Supercomputing Center, Barcelona, Catalonia, Spain.ORCID 0000-0001-8874-6453
Joseph E PowellTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Marc Jan BonderDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0002-8431-3180
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0002-5159-8802
Monique G P van der WijstDepartment of Genetics, University of Groningen, University Medical Center Groningen.ORCID 0000-0003-1520-3970
Funding
Joint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9MPredicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2MImmune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart StudyR01AG075884 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Laura M Raffield · 2022 to 2026
$3.7MModeling the dynamicimpact of rare and common genetic variation on gene expression anddiseaseR35GM139580 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BATTLE, ALEXIS · 2021 to 2025
$3.1MNHGRI NIH HHS U01 HG012009NIA NIH HHS R01 AG075884NIGMS NIH HHS R35 GM139580NIMH NIH HHS R01 MH115676Wellcome Trust
Abstract
Genetic effects on gene expression are often cell type-specific and obscured in bulk analyses. To resolve this context-dependent regulation, we performed a federated
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.