Evidence map›Paper›PMID 41648177›Full record

ArticlebioRxiv : the preprint server for biology2026

The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins.

Marinda Stanton, Bharti Singal, Mahamaya Biswal, Megha Agarwal, Caroline Elizabeth Scheuing, Gerardo Dasaev Vargas, Alex Gao, Casey A Gifford, Tino Pleiner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marinda StantonDepartment of Molecular & Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-4784-5022
Bharti SingalStanford Cryo-Electron Microscopy Center, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9482-5251
Mahamaya BiswalDepartment of Molecular & Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-8995-2635
Megha AgarwalDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1378-3350
Caroline Elizabeth ScheuingDepartment of Molecular & Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-0380-320X
Gerardo Dasaev VargasDepartment of Molecular & Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0001-2643-1453
Alex GaoDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3579-0327
Casey A GiffordDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7757-573X
Tino PleinerDepartment of Molecular & Cellular Physiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-5104-0315

Funding

Molecular Pharmacology Training ProgramT32GM136631 · NIGMS · STANFORD UNIVERSITY · PI BOGYO, MATTHEW, CHEN, JAMES K · 2021 to 2025
$2.0M
NIGMS NIH HHS T32 GM136631
6 · The paper itself

Abstract

Nearly half of the ~5,000 human membrane proteins need to assemble into stoichiometric complexes as part of their biogenesis at the endoplasmic reticulum (ER) membrane. How ER resident biogenesis factors coordinate membrane insertion, folding and assembly is not well understood. Here, we demonstrate that the ER membrane protein complex (EMC) insertase additionally acts as a chaperone to facilitate the assembly of heterotrimeric voltage-gated calcium channels (Ca

Identifiers

PMID41648177
PMCPMC12871136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.