Evidence map›Paper›PMID 41648171›Full record

ArticlebioRxiv : the preprint server for biology2026

Neuronal microscale biophysical instability mediates macroscale network dynamics shaping pathological manifestations.

Vipin Kumar, Victor M Sanchez Franco, Faith S Ferry, Yizhou Xie, Anelise N Hutson, Yutian J Zhang, Skylar D Daniels, Dieu Linh Nguyen, Lucia K Spera, Eleanora M Snyder and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vipin KumarDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Victor M Sanchez FrancoDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Faith S FerryDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Yizhou XieDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Anelise N HutsonDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Yutian J ZhangDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Skylar D DanielsDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Dieu Linh NguyenDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Lucia K SperaDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Eleanora M SnyderDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Anneke KnaussDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Srilakshiya L SudhakarDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Grace Y DuanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Elizabeth M PaulDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Masashi TabuchiDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States.ORCID 0000-0002-8734-6922

Funding

The role of non-canonical neural codes in behaviorR35GM142490 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Masashi Tabuchi · 2021 to 2026
$2.6M
Mechanisms mediating the relationship between temporal coding and sleepR00NS101065 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI TABUCHI, MASASHI · 2020 to 2022
$737k
NIGMS NIH HHS R35 GM142490NINDS NIH HHS R00 NS101065
6 · The paper itself

Abstract

Subtle changes in membrane excitability may contribute to neurological disease, but disease-relevant dynamical signatures that generalize across models remain poorly defined. Here, we quantified variability in action potential initiation in Significance Statement: Linking microscale neuronal changes to macroscale disease phenotypes remains a key challenge in neuroscience biophysics. Here, we show that neurons from

Indexed as

DrosophilaElectrophysiologyEpilepsyiPS cellsMembrane InstabilityNeuronal DynamicsTauopathy

Identifiers

PMID41648171
PMCPMC12871810

What OpenQuestion holds

Textmetadata
LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.