ArticlebioRxiv : the preprint server for biology2026
Differential adenosine signaling and effects of acute caffeine exposure on alternative stress coping styles in zebrafish (
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Changes within neurotransmitter systems are associated with variation in anxiety-related behavior. The adenosine signaling pathway has been associated with anxiety and caffeine has been utilized as a modulator. However, studies have not considered the impact of an individual's stress coping style (e.g. proactive, reactive) and corresponding differences in neuromolecular signaling that can influence the behavioral responses. To assess the role of adenosine signaling, we acutely treated reactive and proactive zebrafish with 50 mg/L caffeine and evaluated anxiety-like behavior using a novel tank diving test (NTDT). We then quantified whole-brain gene expression of genes representing distinct parts of the adenosine signaling pathway: adenosine receptors A1B, A2Aa, A2Ab, and A2B (
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