Evidence map›Paper›PMID 41648158›Full record

ArticlebioRxiv : the preprint server for biology2026

Activation of developmental transcription factors using RNA technology promotes heart repair.

Riley J Leonard, Mason Sweat, Steven Eliason, William Kutschke, Brad A Amendt

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Riley J LeonardLillehei Heart Institute, The University of Minnesota, Minneapolis, MN, 55455 USA.
Mason SweatDepartment of Internal Medicine, University of Texas Southwestern, Dallas TX 75390 USA.
Steven EliasonDepartment of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242 USA.
William KutschkeDepartment of Internal Medicine, The University of Iowa, Iowa City, IA, USA.
Brad A AmendtDepartment of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242 USA.ORCID 0000-0001-6524-1006

Funding

Co-opting Lef-1 and miR-26b activities to regulate dental stem cells and their progenyR01DE028527 · NIDCR · UNIVERSITY OF IOWA · PI AMENDT, BRAD A, CAO, HUOJUN · 2020 to 2024
$2.1M
High Resolution Research UltrasoundS10OD038119 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2025 to 2025
$419k
New Biotechnology using MicroRNA Inhibitors to Regenerate Alveolar BoneR43DE027569 · NIDCR · NATUREMIRI, LLC · PI SANDRA, ALEXANDER · 2018 to 2018
$225k
NIDCR NIH HHS R01 DE028527NIDCR NIH HHS R43 DE027569NIH HHS S10 OD038119
6 · The paper itself

Abstract

Ischemic injury and adverse post-infarction myocardial remodeling are major causes of heart failure. We previously reported that microRNA (

Indexed as

cardiomyocyteheart repairmyocardial infarctPMIS-miR-200ctranscription factors

Identifiers

PMID41648158
PMCPMC12871258

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.