Evidence map›Paper›PMID 41648154›Full record

ArticlebioRxiv : the preprint server for biology2026

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy.

Ishwarya Sankaranarayanan, Khadijah Mazhar, Allison M Barry, Stephanie Shiers, Andi Wangzhou, Julia R Sondermann, Feng Xian, Nikhil Inturi, Michael A Wilde, Eric C Meyers and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ishwarya SankaranarayananCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Khadijah MazharCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Allison M BarryCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Stephanie ShiersCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Andi WangzhouCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Julia R SondermannSystems Biology of Pain, Division of Pharmacology & Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Feng XianSystems Biology of Pain, Division of Pharmacology & Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Nikhil InturiCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Michael A WildeCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Eric C MeyersDepartment of Bioengineering, Erik Jonsson School of Engineering and Computer Science, University of Texas at Dallas, Richardson.
Joseph B LesnakCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Jayden A O'BrienCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Muhammad Saad YousufCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Manuela SchmidtSystems Biology of Pain, Division of Pharmacology & Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Gregory DussorCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Erin VinesSouthwest Transplant Alliance; Dallas, USA.
Peter HortonCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Anna CervantesCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Tariq KhanCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Geoffrey FunkCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
Diana Tavares-FerreiraCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.
PRECISION Human Pain Network
Patrick M DoughertyDepartment of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, USA.
Michele CuratoloDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, USA.
Theodore J PriceCenter for Advanced Pain Studies and Department of Neuroscience, University of Texas at Dallas; Richardson, USA.ORCID 0000-0002-6971-6221

Funding

Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6M
NINDS NIH HHS U19 NS130608
6 · The paper itself

Abstract

Diabetic painful neuropathy (DPN) is characterized by neuropathic pain accompanied by loss of sensory function. We hypothesized that neurodegeneration in the dorsal root ganglion (DRG) could underlie DPN progression. To address this question, we performed multi-omic evaluation on DRGs from otherwise healthy organ donors, donors with diabetes but no neuropathy, and donors with clinically diagnosed DPN. We discovered that the first stages of neurodegeneration begin early in diabetes before the onset of DPN, with Nageotte nodule formation accompanied by apoptotic gene expression and decreased proportion of specific populations of A-fibers in DPN with remodeling of non-neuronal cells. Our findings define DPN as a neurodegenerative disorder of the DRG, identify molecular markers of disease stage, and highlight the need for early intervention to prevent irreversible neurodegeneration.

Identifiers

PMID41648154
PMCPMC12871725

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.