ArticlebioRxiv : the preprint server for biology2026
Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channel.
Logan Elkin, Evgeny G Chulkov, Jonathan Enders, Anthony D Menzel, Sang-Kyu Park, Cheryl L Stucky, Jonathan S Marchant
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Logan ElkinDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Evgeny G ChulkovDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jonathan EndersDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Anthony D MenzelDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sang-Kyu ParkDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Cheryl L StuckyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-6592-0877 Funding
Nociceptive Mechanisms Underlying Sickle Cell PainR01NS070711 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI Bonnie N Dittel, Cheryl Louise Stucky · 2009 to 2026
$8.7MResolving the properties of schistosome TRPMPZQ, the target of the anthelmintic drug praziquantelR01AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Wei Liu, JONATHAN S MARCHANT · 2020 to 2026
$3.1MIdentification of targets of the antiparasitic drug praziquantelR56AI145871 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MARCHANT, JONATHAN S · 2019 to 2019
$438kMechanisms of Neuronal Excitability and Pain in Fabry DiseaseF32NS138223 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI Jonathan David Enders · 2024 to 2026
$229kNIAID NIH HHS R01 AI145871NIAID NIH HHS R56 AI145871NINDS NIH HHS F32 NS138223NINDS NIH HHS R01 NS070711
6 · The paper itselfAbstract
Benzodiazepines represent a major class of drugs prescribed as treatments for anxiety, insomnia and seizures. They act by engaging GABA
Indexed as
burning mouth disorderneuropathypainpolypharmacologyTRP channel
Identifiers
PMID41648152
PMCPMC12871851
What OpenQuestion holds
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