Evidence map›Paper›PMID 41648140›Full record

ArticlebioRxiv : the preprint server for biology2026

Neonatal liver niches program T cell tolerance.

Eva-Lena Stange, Trong-Hieu Nguyen, Dustyn Mendoza, Aiara Lobo Gomes, Marlene Sophia Kohlhepp, Jonas Pes, Shahed Al Bounny, Julian Brueck, Yunus Cetiner, Urs Moerbe and 19 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Eva-Lena StangeInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0001-8277-0663
Trong-Hieu NguyenInstitute of Molecular Medicine, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0009-0005-7185-127X
Dustyn MendozaDepartment of Medicine, Division of Hepatology, and Department of Microbiology & Immunology; Albert Einstein College of Medicine, New York, USA.ORCID 0009-0004-4363-8474
Aiara Lobo GomesInstitute of Molecular Medicine, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0003-4670-6036
Marlene Sophia KohlheppCharité-Universitätsmedizin Berlin, Department of Hepatology & Gastroenterology; Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.ORCID 0000-0002-2828-1663
Jonas PesInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0009-0004-6440-4853
Shahed Al BounnyInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0009-0007-4637-4349
Julian BrueckInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.
Yunus CetinerInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.
Urs MoerbeDepartment of Immunology & Microbiology, LEO Foundation Skin Immunology Research Center, University of Copenhagen; Copenhagen, Denmark.ORCID 0000-0001-8747-437X
Milas UgurInstitute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID 0000-0003-2115-5389
Cristina KalbermatterDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.ORCID 0009-0003-3689-291X
Jarrett Lopez-ScarimDepartment of Medicine, Division of Hepatology, and Department of Microbiology & Immunology; Albert Einstein College of Medicine, New York, USA.ORCID 0000-0002-6941-2797
Aline DupontInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0002-5290-2810
Susan A V JenningsFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0009-0006-9932-0056
Julia HeckmannDepartment of Pediatrics, University Hospital Würzburg; Würzburg, Germany.ORCID 0000-0002-7173-0954
Aaron Silva-SanchezDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham Heersink School of Medicine; Birmingham, AL 35294, USA.ORCID 0000-0002-1882-2534
Solveig RungeDepartment of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU); Erlangen, Germany.ORCID 0000-0002-9193-476X
Christoph KuppeDivision of Nephrology and Clinical Immunology,Medical Faculty, RWTH Aachen University; Aachen, Germany.ORCID 0000-0003-4597-9833
Oliver PabstInstitute of Molecular Medicine, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0002-5533-883X
Thomas ClavelFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0002-7229-5595
Dorothee ViemannDepartment of Pediatrics, University Hospital Würzburg; Würzburg, Germany.ORCID 0000-0002-9009-3559
Stephan P RosshartDepartment of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU); Erlangen, Germany.ORCID 0000-0002-6989-8686
Vuk CerovicInstitute of Molecular Medicine, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0003-1392-0669
Stephanie C Ganal-VonarburgDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.ORCID 0000-0002-2548-7754
Adrien GuillotDepartment of Pediatrics, University Hospital Würzburg; Würzburg, Germany.ORCID 0000-0002-6002-9986
Eva BillerbeckDepartment of Medicine, Division of Hepatology, and Department of Microbiology & Immunology; Albert Einstein College of Medicine, New York, USA.ORCID 0000-0002-0477-1748
Mathias W HornefInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0001-6096-9110
Natalia TorowInstitute of Medical Microbiology, University Hospital RWTH Aachen; Aachen, Germany.ORCID 0000-0003-3013-8724

Funding

New insights into the functional diversity of the hepatic antiviral T cell response during hepacivirus infection in vivoR01AI170725 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BILLERBECK, EVA · 2022 to 2025
$2.2M
NIAID NIH HHS R01 AI170725
6 · The paper itself

Abstract

After birth, the immune system must learn to tolerate a rapidly changing milieu of commensals and self while remaining ready for pathogens. Here we characterize the neonatal liver as a central hub in this process: In postnatal week 1-2, the liver hosts a developmentally encoded, microbiota-independent expansion of regulatory T cells (Tregs) that coexists with microbiota-tuned conventional wave of activated CD4

Identifiers

PMID41648140
PMCPMC12871242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.