Evidence map›Paper›PMID 41648125›Full record

ArticlebioRxiv : the preprint server for biology2026

Decoding the cell intrinsic and extrinsic roles of PRC2 in early embryogenesis.

Chengjie Zhou, Meng Wang, Zhiyuan Chen, Yi Zhang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chengjie ZhouHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA.
Meng WangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA.
Zhiyuan ChenHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA.
Yi ZhangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA.

Funding

Understanding the mechanism of pre- to naïve- to formative- pluripotency transitionsR01HD116750 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Yi Zhang · 2025 to 2026
$1.5M
Genomic and functional analyses of Polycomb group proteins in mouse preimplantation developmentR00HD104902 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI CHEN, ZHIYUAN · 2023 to 2025
$670k
NICHD NIH HHS R00 HD104902NICHD NIH HHS R01 HD116750
6 · The paper itself

Abstract

Early embryogenesis is accompanied by dynamic epigenetic modifications. While such dynamics are important in cell intrinsic regulation of gene expression, their extrinsic roles in mediating intercellular communication during early embryogenesis is less understood. Using the protein degradation tag (dTAG) system, here we decode stage- and lineage-specific functions of

Indexed as

epiblast specificationH3K27me3maternal-to-zygotic transitionPolycombprimordial germ cells

Identifiers

PMID41648125
PMCPMC12871610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.