Evidence map›Paper›PMID 41648115›Full record

ArticlebioRxiv : the preprint server for biology2026

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.

Ujani Chakraborty, Emma Christina Saccone, Grisel Cruz-Becerra, Laiba F Khan, Nina Arslanovic, Rhiannon Aguilar, Susan L Gloor, Sabrina R Hunt, Heather J Folkwein, Natalia Ledo Husby and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Ujani ChakrabortyWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Emma Christina SacconeCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Grisel Cruz-BecerraDepartment of Molecular Biology, UCSD, 9500 Gilman Drive, San Diego, CA 92093.ORCID 0000-0001-6297-4132
Laiba F KhanEpiCypher Inc., Durham, NC 27709, USA.
Nina ArslanovicWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Rhiannon AguilarWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.
Susan L GloorEpiCypher Inc., Durham, NC 27709, USA.
Sabrina R HuntEpiCypher Inc., Durham, NC 27709, USA.
Heather J FolkweinCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Natalia Ledo HusbyEpiCypher Inc., Durham, NC 27709, USA.
Keith E MaierEpiCypher Inc., Durham, NC 27709, USA.
Matthew R MarundeEpiCypher Inc., Durham, NC 27709, USA.
Noah K SchomburgEpiCypher Inc., Durham, NC 27709, USA.
Anup VaidyaEpiCypher Inc., Durham, NC 27709, USA.
Martis W CowlesEpiCypher Inc., Durham, NC 27709, USA.
Bryan J VentersEpiCypher Inc., Durham, NC 27709, USA.
George KassavetisDepartment of Molecular Biology, UCSD, 9500 Gilman Drive, San Diego, CA 92093.
Zu-Wen SunEpiCypher Inc., Durham, NC 27709, USA.
James T KadonagaDepartment of Molecular Biology, UCSD, 9500 Gilman Drive, San Diego, CA 92093.ORCID 0000-0002-2075-9458
Jean-Paul ArmacheCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Michael-Christopher KeoghEpiCypher Inc., Durham, NC 27709, USA.ORCID 0000-0002-2219-8623
Jessica K TylerWeill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.

Funding

Mechanisms of Eukaryotic Gene RegulationR35GM118060 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI James T. Kadonaga · 2016 to 2026
$7.5M
Development of efficient quantitative chromatin profiling in kit and high-throughput formatsR44HG010640 · NHGRI · EPICYPHER, INC. · PI KEOGH, MICHAEL-CHRISTOPHER, VENTERS, BRYAN J · 2020 to 2022
$2.4M
Novel pathways that regulate DNA double-strand break repair events in mammalian cellsR35GM139816 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TYLER, JESSICA K · 2021 to 2025
$2.1M
Accelerated discovery of methylation targeted therapeutic developmentR44CA212733 · NCI · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$2.1M
HEI: Acquisition of a Talos Arctica G2S10OD026822 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAFENSTEIN, SUSAN · 2019 to 2019
$2.0M
Multiplex nucleosome-based profiling for the development of next-generation chromatin labeling reagentsR44GM136172 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2020 to 2021
$1.8M
High-throughput methyltransferase assays using recombinant nucleosome substratesR44GM117683 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$1.7M
Structural and Functional Studies of lncRNAs in Gene ActivationR01GM149780 · NIGMS · DREXEL UNIVERSITY · PI Srinivas Somarowthu · 2023 to 2026
$1.7M
Development of highly specific and renewable chromatin labelling reagentsR43GM134834 · NIGMS · EPICYPHER, INC. · PI JOHNSTONE, ANDREA LYNN · 2019 to 2019
$300k
NCI NIH HHS R44 CA212733NHGRI NIH HHS R44 HG010640NIGMS NIH HHS R01 GM149780NIGMS NIH HHS R35 GM118060NIGMS NIH HHS R35 GM139816NIGMS NIH HHS R43 GM134834NIGMS NIH HHS R44 GM117683NIGMS NIH HHS R44 GM136172NIH HHS S10 OD026822
6 · The paper itself

Abstract

The nucleosome acidic patch is a hub of coordinated engagement by proteins that regulate genomic function. Here we report that

Indexed as

Chromatincompetitioncryo-EMgene silencinggenome stabilitynucleosome acidic patch

Identifiers

PMID41648115
PMCPMC12871379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.